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Reduction in N-Acetylglucosaminyltransferase-I Activity Decreases Survivability and Delays Development of Zebrafish

A lack of complex and hybrid types of N-glycans in mice is embryonically lethal due to neural tube maldevelopment. N-acetylglucosaminyltransferase-I (GnT-I; Mgat1) catalyzes a required step for converting oligomannose N-glycans into hybrid and complex N-glycans. Unlike mice, zebrafish have two Mgat1...

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Detalles Bibliográficos
Autores principales:	Hall, M. Kristen, Hatchett, Cody J., Shalygin, Sergei, Azadi, Parastoo, Schwalbe, Ruth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669939/ https://www.ncbi.nlm.nih.gov/pubmed/37998752 http://dx.doi.org/10.3390/cimb45110575

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