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Doxorubicin-Induced Cardiac Senescence Is Alleviated Following Treatment with Combined Polyphenols and Micronutrients through Enhancement in Mitophagy
Oxidative stress and impaired mitophagy are the hallmarks of cardiomyocyte senescence. Specifically, a decrease in mitophagic flux leads to the accumulation of damaged mitochondria and the development of senescence through increased ROS and other mediators. In this study, we describe the preventive...
Autores principales: | Foglio, Eleonora, D’Avorio, Erica, Vitiello, Laura, Masuelli, Laura, Bei, Roberto, Pacifici, Francesca, Della-Morte, David, Mirabilii, Simone, Ricciardi, Maria Rosaria, Tafuri, Agostino, Garaci, Enrico, Russo, Matteo Antonio, Tafani, Marco, Limana, Federica |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670650/ https://www.ncbi.nlm.nih.gov/pubmed/37998340 http://dx.doi.org/10.3390/cells12222605 |
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