MLH1 Promoter Methylation Could Be the Second Hit in Lynch Syndrome Carcinogenesis

(1) Background: MLH1 hypermethylation is an epigenetic alteration in the tumorigenesis of colorectal cancer (CRC) and endometrial cancer (EC), causing gene silencing, and, as a consequence, microsatellite instability. Commonly, MLH1 hypermethylation is considered a somatic and sporadic event in canc...

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Detalles Bibliográficos
Autores principales: Carnevali, Ileana Wanda, Cini, Giulia, Libera, Laura, Sahnane, Nora, Facchi, Sofia, Viel, Alessandra, Sessa, Fausto, Tibiletti, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670941/
https://www.ncbi.nlm.nih.gov/pubmed/38003003
http://dx.doi.org/10.3390/genes14112060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10670941/
https://www.ncbi.nlm.nih.gov/pubmed/38003003
http://dx.doi.org/10.3390/genes14112060

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