Multiomics of GCN4-Dependent Replicative Lifespan Extension Models Reveals Gcn4 as a Regulator of Protein Turnover in Yeast

We have shown that multiple tRNA synthetase inhibitors can increase lifespan in both the nematode C. elegans and the budding yeast S. cerevisiae by acting through the conserved transcription factor Gcn4 (yeast)/ATF-4 (worms). To further understand the biology downstream from this conserved transcrip...

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Detalles Bibliográficos
Autores principales: Mariner, Blaise L., Felker, Daniel P., Cantergiani, Ryla J., Peterson, Jack, McCormick, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671045/
https://www.ncbi.nlm.nih.gov/pubmed/38003352
http://dx.doi.org/10.3390/ijms242216163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671045/
https://www.ncbi.nlm.nih.gov/pubmed/38003352
http://dx.doi.org/10.3390/ijms242216163

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