Hepatic NLRP3-Derived Hsp70 Binding to TLR4 Mediates MASLD to MASH Progression upon Inhibition of PP2A by Harmful Algal Bloom Toxin Microcystin, a Second Hit

Harmful algal bloom toxin microcystin has been associated with metabolic dysfunction-associated steatotic liver disease (MASLD) progression and hepatocellular carcinoma, though the mechanisms remain unclear. Using an established mouse model of MASLD, we show that the NLRP3–Hsp70–TLR4 axis drives in...

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Detalles Bibliográficos
Autores principales: Roy, Subhajit, Saha, Punnag, Bose, Dipro, Trivedi, Ayushi, More, Madhura, Xiao, Shuo, Diehl, Anna Mae, Chatterjee, Saurabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671242/
https://www.ncbi.nlm.nih.gov/pubmed/38003543
http://dx.doi.org/10.3390/ijms242216354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671242/
https://www.ncbi.nlm.nih.gov/pubmed/38003543
http://dx.doi.org/10.3390/ijms242216354

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