Functional Characterization of Novel MC4R Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar

The leptin–melanocortin pathway is pivotal in appetite and energy homeostasis. Pathogenic variants in genes involved in this pathway lead to severe early-onset monogenic obesity (MO). The MC4R gene plays a central role in leptin–melanocortin signaling, and heterozygous variants in this gene are the...

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Detalles Bibliográficos
Autores principales: Mohammed, Idris, Selvaraj, Senthil, Ahmed, Wesam S., Al-Barazenji, Tara, Hammad, Ayat S, Dauleh, Hajar, Saraiva, Luis R., Al-Shafai, Mashael, Hussain, Khalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671262/
https://www.ncbi.nlm.nih.gov/pubmed/38003551
http://dx.doi.org/10.3390/ijms242216361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671262/
https://www.ncbi.nlm.nih.gov/pubmed/38003551
http://dx.doi.org/10.3390/ijms242216361

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