RNF138 Downregulates Antiviral Innate Immunity by Inhibiting IRF3 Activation

A viral infection activates the transcription factors IRF3 and NF-κB, which synergistically induces type I interferons (IFNs). Here, we identify the E3 ubiquitin ligase RNF138 as an important negative regulator of virus-triggered IRF3 activation and IFN-β induction. The overexpression of RNF138 inhi...

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Detalles Bibliográficos
Autores principales: Zeng, Xianhuang, Liu, Chaozhi, Fan, Jinhao, Zou, Jiabin, Guo, Mingxiong, Sun, Guihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671598/
https://www.ncbi.nlm.nih.gov/pubmed/38003298
http://dx.doi.org/10.3390/ijms242216110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671598/
https://www.ncbi.nlm.nih.gov/pubmed/38003298
http://dx.doi.org/10.3390/ijms242216110

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