The Interplay of Permeability, Metabolism, Transporters, and Dosing in Determining the Dynamics of the Tissue/Plasma Partition Coefficient and Volume of Distribution—A Theoretical Investigation Using Permeability-Limited, Physiologically Based Pharmacokinetic Modeling

A permeability-limited physiologically based pharmacokinetic (PBPK) model featuring four subcompartments (corresponding to the intracellular and extracellular water of the tissue, the residual plasma, and blood cells) for each tissue has been developed in MATLAB/SimBiology and applied to various wha...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaohua, Lu, Zhang, Mian, Sychterz, Caroline, Chang, Ming, Schmidt, Brian James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671645/
https://www.ncbi.nlm.nih.gov/pubmed/38003416
http://dx.doi.org/10.3390/ijms242216224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671645/
https://www.ncbi.nlm.nih.gov/pubmed/38003416
http://dx.doi.org/10.3390/ijms242216224

Ejemplares similares