Design, Synthesis, and Antitumor Activity Evaluation of Proteolysis-Targeting Chimeras as Degraders of Extracellular Signal-Regulated Kinases 1/2

Inhibition of the extracellular signal-regulated kinases 1/2 (ERK1/2) alone or in combination with other targets has emerged as a promising treatment strategy for a variety of human tumors. In addition to the development of inhibitors, the development of ERK1/2 degraders is an alternative approach t...

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Detalles Bibliográficos
Autores principales: Pan, Pengming, He, Yichao, Geng, Tongtong, Li, Zhongtang, Li, Zhongjun, Meng, Xiangbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671693/
https://www.ncbi.nlm.nih.gov/pubmed/38003480
http://dx.doi.org/10.3390/ijms242216290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671693/
https://www.ncbi.nlm.nih.gov/pubmed/38003480
http://dx.doi.org/10.3390/ijms242216290

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