Drug-Induced Conformational Dynamics of P-Glycoprotein Underlies the Transport of Camptothecin Analogs

P-glycoprotein (Pgp) plays a pivotal role in drug bioavailability and multi-drug resistance development. Understanding the protein’s activity and designing effective drugs require insight into the mechanisms underlying Pgp-mediated transport of xenobiotics. In this study, we investigated the drug-in...

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Detalles Bibliográficos
Autores principales: Mensah, Gershon A. K., Schaefer, Katherine G., Bartlett, Michael G., Roberts, Arthur G., King, Gavin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671697/
https://www.ncbi.nlm.nih.gov/pubmed/38003248
http://dx.doi.org/10.3390/ijms242216058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671697/
https://www.ncbi.nlm.nih.gov/pubmed/38003248
http://dx.doi.org/10.3390/ijms242216058

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