Oral Bioavailability and Pharmacokinetics of Sildenafil Orally Disintegrating Tablets under Various Gastric pH Levels Following Administration of Omeprazole in Rats

Sildenafil citrate, an oral drug used to treat erectile dysfunction, has low water solubility and oral bioavailability. The solubility is greatly influenced by the pH, changing from 37.25 mg/mL to 0.22 mg/mL with a change in pH from 1.2 to 8.0. This indicates that the absorption may decrease in pati...

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Detalles Bibliográficos
Autores principales: Shih, Chin-Yu, Chen, Chao-Yi, Lin, Hsien-Te, Liao, Ying-Ju, Liang, Yao-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671963/
https://www.ncbi.nlm.nih.gov/pubmed/38004266
http://dx.doi.org/10.3390/life13112126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671963/
https://www.ncbi.nlm.nih.gov/pubmed/38004266
http://dx.doi.org/10.3390/life13112126

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