DGKα/ζ inhibition lowers the TCR affinity threshold and potentiates antitumor immunity

Diacylglycerol kinases (DGKs) attenuate diacylglycerol (DAG) signaling by converting DAG to phosphatidic acid, thereby suppressing pathways downstream of T cell receptor signaling. Using a dual DGKα/ζ inhibitor (DGKi), tumor-specific CD8 T cells with different affinities (TRP1(high) and TRP1(low)),...

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Detalles Bibliográficos
Autores principales: Kureshi, Rakeeb, Bello, Elisa, Kureshi, Courtney T.S., Walsh, Michael J., Lippert, Victoria, Hoffman, Megan T., Dougan, Michael, Longmire, Tyler, Wichroski, Michael, Dougan, Stephanie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672170/
https://www.ncbi.nlm.nih.gov/pubmed/38000024
http://dx.doi.org/10.1126/sciadv.adk1853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672170/
https://www.ncbi.nlm.nih.gov/pubmed/38000024
http://dx.doi.org/10.1126/sciadv.adk1853

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