A First in Human Clinical Trial Assessing the Safety and Immunogenicity of Two Intradermally Delivered Enterotoxigenic Escherichia coli CFA/I Fimbrial Tip Adhesin Antigens with and without Heat-Labile Enterotoxin with Mutation LT(R192G)

Introduction: Enterotoxigenic E. coli (ETEC) is a leading cause of diarrhea in travelers as well as for children living in low- to middle-income countries. ETEC adhere to intestinal epithelium via colonization factors (CFs). CFA/I, a common CF, is composed of a polymeric stalk and a tip-localized mi...

Descripción completa

Detalles Bibliográficos
Autores principales: Gutiérrez, Ramiro L., Riddle, Mark S., Porter, Chad K., Maciel, Milton, Poole, Steven T., Laird, Renee M., Lane, Michelle, Turiansky, George W., Jarell, Abel, Savarino, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Project Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672875/
https://www.ncbi.nlm.nih.gov/pubmed/38004700
http://dx.doi.org/10.3390/microorganisms11112689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672875/
https://www.ncbi.nlm.nih.gov/pubmed/38004700
http://dx.doi.org/10.3390/microorganisms11112689

Ejemplares similares