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A First in Human Clinical Trial Assessing the Safety and Immunogenicity of Two Intradermally Delivered Enterotoxigenic Escherichia coli CFA/I Fimbrial Tip Adhesin Antigens with and without Heat-Labile Enterotoxin with Mutation LT(R192G)

Introduction: Enterotoxigenic E. coli (ETEC) is a leading cause of diarrhea in travelers as well as for children living in low- to middle-income countries. ETEC adhere to intestinal epithelium via colonization factors (CFs). CFA/I, a common CF, is composed of a polymeric stalk and a tip-localized mi...

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Detalles Bibliográficos
Autores principales:	Gutiérrez, Ramiro L., Riddle, Mark S., Porter, Chad K., Maciel, Milton, Poole, Steven T., Laird, Renee M., Lane, Michelle, Turiansky, George W., Jarell, Abel, Savarino, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Project Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672875/ https://www.ncbi.nlm.nih.gov/pubmed/38004700 http://dx.doi.org/10.3390/microorganisms11112689

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