1,1,1,3,3,3-Hexafluoro-2-Propanol-Promoted Friedel–Crafts Reaction: Metal-Free Synthesis of C3-Difluoromethyl Carbinol-Containing Imidazo[1,2-a]pyridines at Room Temperature

A facile and efficient method has been developed for the synthesis of C3-difluoromethyl carbinol-containing imidazo[1,2-a]pyridines at room temperature via the HFIP-promoted Friedel–Crafts reaction of difluoroacetaldehyde ethyl hemiacetal and imidazo[1,2-a]pyridines. This strategy could be applied t...

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Detalles Bibliográficos
Autores principales: Gao, Juanjuan, Liu, Zhaowen, Guo, Xiaohua, Wu, Longhui, Chen, Zhixi, Yang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672982/
https://www.ncbi.nlm.nih.gov/pubmed/38005245
http://dx.doi.org/10.3390/molecules28227522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672982/
https://www.ncbi.nlm.nih.gov/pubmed/38005245
http://dx.doi.org/10.3390/molecules28227522

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