Selective Stability Indicating Liquid Chromatographic Method Based on Quality by Design Framework and In Silico Toxicity Assessment for Infigratinib and Its Degradation Products

Infigratinib, a protein kinase inhibitor employed in the therapeutic management of cholangiocarcinoma, was subjected to various stress conditions, including hydrolytic (acidic and alkaline), oxidative, photolytic, and thermal stress, in accordance with the rules established by the International Coun...

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Detalles Bibliográficos
Autores principales: Ali, Awadh M., Alanazi, Mohammed M., Attwa, Mohamed W., Darwish, Hany W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673276/
https://www.ncbi.nlm.nih.gov/pubmed/38005198
http://dx.doi.org/10.3390/molecules28227476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673276/
https://www.ncbi.nlm.nih.gov/pubmed/38005198
http://dx.doi.org/10.3390/molecules28227476

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