Conformational Stability of the N-Terminal Region of MDM2

MDM2 is an E3 ubiquitin ligase which is crucial for the degradation and inhibition of the key tumor-suppressor protein p53. In this work, we explored the stability and the conformational features of the N-terminal region of MDM2 (N-MDM2), through which it binds to the p53 protein as well as other pr...

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Detalles Bibliográficos
Autores principales: Rizzuti, Bruno, Abian, Olga, Velazquez-Campoy, Adrián, Neira, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673428/
https://www.ncbi.nlm.nih.gov/pubmed/38005300
http://dx.doi.org/10.3390/molecules28227578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673428/
https://www.ncbi.nlm.nih.gov/pubmed/38005300
http://dx.doi.org/10.3390/molecules28227578

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