Design, Synthesis and Bioactivity Evaluation of Heterocycle-Containing Mono- and Bisphosphonic Acid Compounds

Fosmidomycin (FOS) is a naturally occurring compound active against the 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) enzyme in the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, and using it as a template for lead structure design is an effective strategy to develop new active compounds...

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Detalles Bibliográficos
Autores principales: Wu, Xin, Yang, Zili, Bu, Mengwei, Duan, Jiang, Zhang, Aidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673511/
https://www.ncbi.nlm.nih.gov/pubmed/38005231
http://dx.doi.org/10.3390/molecules28227509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673511/
https://www.ncbi.nlm.nih.gov/pubmed/38005231
http://dx.doi.org/10.3390/molecules28227509

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