Readministration of high-dose adeno-associated virus gene therapy vectors enabled by ImmTOR nanoparticles combined with B cell-targeted agents

Tolerogenic ImmTOR nanoparticles encapsulating rapamycin have been demonstrated to mitigate immunogenicity of adeno-associated virus (AAV) gene therapy vectors, enhance levels of transgene expression, and enable redosing of AAV at moderate vector doses of 2 to 5E12 vg/kg. However, recent clinical tr...

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Detalles Bibliográficos
Autores principales: Ilyinskii, Petr O, Roy, Christopher, Michaud, Alicia, Rizzo, Gina, Capela, Teresa, Leung, Sheldon S, Kishimoto, Takashi Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673641/
https://www.ncbi.nlm.nih.gov/pubmed/38024395
http://dx.doi.org/10.1093/pnasnexus/pgad394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673641/
https://www.ncbi.nlm.nih.gov/pubmed/38024395
http://dx.doi.org/10.1093/pnasnexus/pgad394

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