Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1α

Hypoxia inducible factor-1α (HIF-1α) is a crucial therapeutic target in various diseases, including cancer and fibrosis. We previously demonstrated that transfection with double-stranded RNA (dsRNA), including polyI:C and the dsRNA genome of mammalian orthoreovirus, resulted in significant reduction...

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Detalles Bibliográficos
Autores principales: Hotani, Takuma, Nakagawa, Kanako, Tsukamoto, Tomohito, Mizuguchi, Hiroyuki, Sakurai, Fuminori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673737/
https://www.ncbi.nlm.nih.gov/pubmed/37615898
http://dx.doi.org/10.1007/s10753-023-01881-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673737/
https://www.ncbi.nlm.nih.gov/pubmed/37615898
http://dx.doi.org/10.1007/s10753-023-01881-8

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