Cargando…

Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1α

Hypoxia inducible factor-1α (HIF-1α) is a crucial therapeutic target in various diseases, including cancer and fibrosis. We previously demonstrated that transfection with double-stranded RNA (dsRNA), including polyI:C and the dsRNA genome of mammalian orthoreovirus, resulted in significant reduction...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hotani, Takuma, Nakagawa, Kanako, Tsukamoto, Tomohito, Mizuguchi, Hiroyuki, Sakurai, Fuminori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673737/ https://www.ncbi.nlm.nih.gov/pubmed/37615898 http://dx.doi.org/10.1007/s10753-023-01881-8

Ejemplares similares

Systemically Administered Reovirus-Induced Downregulation of Hypoxia Inducible Factor-1α in Subcutaneous Tumors
por: Hotani, Takuma, et al.
Publicado: (2018)

ITCH facilitates proteasomal degradation of TXNIP in hypoxia‐ induced lung cancer cells
por: Sun, Qian, et al.
Publicado: (2022)

RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α
por: van Hagen, Martijn, et al.
Publicado: (2010)

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression
por: Liu, Qiangqiang, et al.
Publicado: (2022)

miR-27b antagonizes BMP signaling in early differentiation of human induced pluripotent stem cells
por: Lim, Jaeeun, et al.
Publicado: (2021)

Inhibition of Proteasomal Degradation of Rpn4 Impairs Nonhomologous End-Joining Repair of DNA Double-Strand Breaks
por: Ju, Donghong, et al.
Publicado: (2010)

Ligand-induced estrogen receptor α degradation by the proteasome: new actors?
por: Calligé, Mathilde, et al.
Publicado: (2006)

Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia
por: Bi, Jianling, et al.
Publicado: (2017)

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation
por: Lobbestael, E., et al.
Publicado: (2016)

Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila
por: Lőw, Péter, et al.
Publicado: (2013)

Adenovirus vector-based vaccine for infectious diseases
por: Sakurai, Fuminori, et al.
Publicado: (2022)

miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers
por: Sakurai, Fuminori, et al.
Publicado: (2019)

Double-Stranded Polynucleotides as Interferon Inducers
por: Field, A. K., et al.
Publicado: (1970)

Xanthine Oxidase Mediates Hypoxia-Inducible Factor-2α Degradation by Intermittent Hypoxia
por: Nanduri, Jayasri, et al.
Publicado: (2013)

Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35
por: Ono, Ryosuke, et al.
Publicado: (2021)

Hypoxia and Hypoxia Mimetics Decrease Aquaporin 5 (AQP5) Expression through Both Hypoxia Inducible Factor-1α and Proteasome-Mediated Pathways
por: Kawedia, Jitesh D., et al.
Publicado: (2013)

Proteasome in action: substrate degradation by the 26S proteasome
por: Sahu, Indrajit, et al.
Publicado: (2021)

Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine
por: Ozawa, Tatsuya, et al.
Publicado: (2015)

Hypoxia-induced 26S proteasome dysfunction increases immunogenicity of mesenchymal stem cells
por: Abu-El-Rub, Ejlal, et al.
Publicado: (2019)

The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
por: Jung, Tobias, et al.
Publicado: (2013)

Comparative analysis of double-stranded RNA degradation and processing in insects
por: Singh, Indrakant K., et al.
Publicado: (2017)

Selective mitochondrial DNA degradation following double-strand breaks
por: Moretton, Amandine, et al.
Publicado: (2017)

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
por: Tanaka, Atsushi, et al.
Publicado: (2010)

Inactivation of beta1 integrin induces proteasomal degradation of Myc oncoproteins
por: Sasada, Manabu, et al.
Publicado: (2019)

Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, induces accumulation of DNA double-strand breaks
por: Ihara, Makoto, et al.
Publicado: (2020)

Fulvestrant-Induced Cell Death and Proteasomal Degradation of Estrogen Receptor α Protein in MCF-7 Cells Require the CSK c-Src Tyrosine Kinase
por: Yeh, Wei-Lan, et al.
Publicado: (2013)

Proteolytic Disassembly of Viral Outer Capsid Proteins Is Crucial for Reovirus-Mediated Type-I Interferon Induction in Both Reovirus-Susceptible and Reovirus-Refractory Tumor Cells
por: Katayama, Yuki, et al.
Publicado: (2015)

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction
por: Nakamori, Daiki, et al.
Publicado: (2017)

Neonatal Gene Therapy for Hemophilia B by a Novel Adenovirus Vector Showing Reduced Leaky Expression of Viral Genes
por: Iizuka, Shunsuke, et al.
Publicado: (2017)

Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus
por: Ono, Ryosuke, et al.
Publicado: (2022)

Interaction of the Double-Strand Break Repair Kinase DNA-PK and Estrogen Receptor-α
por: Medunjanin, Senad, et al.
Publicado: (2010)

Hypoxia-induced alterations in the lung ubiquitin proteasome system during pulmonary hypertension pathogenesis
por: Wade, Brandy E., et al.
Publicado: (2018)

Short-term detection of gastric genotoxicity using the DNA double-strand break marker γ-H2AX
por: Okabe, Asako, et al.
Publicado: (2019)

Role of protein kinase R in double‐stranded RNA‐induced expression of nitric oxide synthase in human astroglia
por: Auch, Corey J, et al.
Publicado: (2004)

An Inducible System for Rapid Degradation of Specific Cellular Proteins Using Proteasome Adaptors
por: Wilmington, Shameika R., et al.
Publicado: (2016)

The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes()
por: Jung, Tobias, et al.
Publicado: (2013)

Extrasynaptic N-Methyl-d-aspartate (NMDA) Receptor Stimulation Induces Cytoplasmic Translocation of the CDKL5 Kinase and Its Proteasomal Degradation
por: Rusconi, Laura, et al.
Publicado: (2011)

Glucose Deprivation Triggers Protein Kinase C-dependent β-Catenin Proteasomal Degradation
por: Choi, Seung-Won, et al.
Publicado: (2015)

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection
por: Sakurai, Fuminori, et al.
Publicado: (2017)

Proteasomal Degradation of TRIM5α during Retrovirus Restriction
por: Rold, Christopher James, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_4uqqcv8sk3saj1ike61m67v37l