p53 and p21 dynamics encode single-cell DNA damage levels, fine-tuning proliferation and shaping population heterogeneity

Cells must accurately and quickly detect DNA damage through a set of checkpoint mechanisms that enable repair and control proliferation. Heterogeneous levels of cellular stress and noisy signaling processes can lead to phenotypic variability but little is known about their role in underlying prolife...

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Detalles Bibliográficos
Autores principales: Gutu, Nica, Binish, Neha, Keilholz, Ulrich, Herzel, Hanspeter, Granada, Adrián E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673849/
https://www.ncbi.nlm.nih.gov/pubmed/38001355
http://dx.doi.org/10.1038/s42003-023-05585-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673849/
https://www.ncbi.nlm.nih.gov/pubmed/38001355
http://dx.doi.org/10.1038/s42003-023-05585-5

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