Design, Synthesis, In Vitro, and In Silico Studies of New N(5)-Substituted-pyrazolo[3,4-d]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors

CDK2 is a key player in cell cycle processes. It has a crucial role in the progression of various cancers. Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are two common cancers that affect humans worldwide. The available therapeutic options suffer from many drawbacks including high toxic...

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Detalles Bibliográficos
Autores principales: Zaki, Waheed A., El-Sayed, Selwan M., Alswah, Mohamed, El-Morsy, Ahmed, Bayoumi, Ashraf H., Mayhoub, Abrahman S., Moustafa, Walaa H., Awaji, Aeshah A., Roh, Eun Joo, Hassan, Ahmed H.E., Mahmoud, Kazem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674233/
https://www.ncbi.nlm.nih.gov/pubmed/38004458
http://dx.doi.org/10.3390/ph16111593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674233/
https://www.ncbi.nlm.nih.gov/pubmed/38004458
http://dx.doi.org/10.3390/ph16111593

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