Solubility and Physical Stability Enhancement of Loratadine by Preparation of Co-Amorphous Solid Dispersion with Chlorpheniramine and Polyvinylpyrrolidone

Loratadine (LRD), a non-sedating and slow-acting antihistamine, is often given in combination with short-onset chlorpheniramine maleate (CPM) to increase efficacy. However, LRD has poor water solubility resulting in low bioavailability. The aim of this study was to improve LRD solubility by preparin...

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Detalles Bibliográficos
Autores principales: Suknuntha, Krit, Khumpirapang, Nattakanwadee, Tantishaiyakul, Vimon, Okonogi, Siriporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674291/
https://www.ncbi.nlm.nih.gov/pubmed/38004537
http://dx.doi.org/10.3390/pharmaceutics15112558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674291/
https://www.ncbi.nlm.nih.gov/pubmed/38004537
http://dx.doi.org/10.3390/pharmaceutics15112558

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