Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays

Trace amine-associated receptor 1 (TAAR1) is an attractive target for the design of innovative drugs to be applied in diverse pharmacological settings. Due to a non-negligible structural similarity with endogenous ligands, most of the agonists developed so far resulted in being affected by a low sel...

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Detalles Bibliográficos
Autores principales: Cichero, Elena, Francesconi, Valeria, Casini, Beatrice, Casale, Monica, Kanov, Evgeny, Gerasimov, Andrey S., Sukhanov, Ilya, Savchenko, Artem, Espinoza, Stefano, Gainetdinov, Raul R., Tonelli, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674299/
https://www.ncbi.nlm.nih.gov/pubmed/38004497
http://dx.doi.org/10.3390/ph16111632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674299/
https://www.ncbi.nlm.nih.gov/pubmed/38004497
http://dx.doi.org/10.3390/ph16111632

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