Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin

Clostridium perfringens enterotoxin (CpE) is a β-pore forming toxin that disrupts gastrointestinal homeostasis in mammals by binding membrane protein receptors called claudins. Although structures of CpE fragments bound to claudins have been determined, the mechanisms that trigger CpE activation and...

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Detalles Bibliográficos
Autores principales: Ogbu, Chinemerem P., Kapoor, Srajan, Vecchio, Alex J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674488/
https://www.ncbi.nlm.nih.gov/pubmed/37999500
http://dx.doi.org/10.3390/toxins15110637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674488/
https://www.ncbi.nlm.nih.gov/pubmed/37999500
http://dx.doi.org/10.3390/toxins15110637

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