Design, Synthesis, Evaluation and Molecular Dynamics Simulation of Dengue Virus NS5-RdRp Inhibitors

Dengue virus (DENV) is a major mosquito-borne human pathogen in tropical countries; however, there are currently no targeted antiviral treatments for DENV infection. Compounds 27 and 29 have been reported to be allosteric inhibitors of DENV RdRp with potent inhibitory effects. In this study, the str...

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Detalles Bibliográficos
Autores principales: Zong, Keli, Li, Wei, Xu, Yijie, Zhao, Xu, Cao, Ruiyuan, Yan, Hong, Li, Xingzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674617/
https://www.ncbi.nlm.nih.gov/pubmed/38004490
http://dx.doi.org/10.3390/ph16111625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674617/
https://www.ncbi.nlm.nih.gov/pubmed/38004490
http://dx.doi.org/10.3390/ph16111625

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