A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins

Background: Clostridioides difficile toxins TcdA and TcdB are responsible for diarrhea and colitis. Lack of functional studies in organoid models of the gut prompted us to elucidate the toxin’s effects on epithelial barrier function and the molecular mechanisms for diarrhea and inflammation. Methods...

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Detalles Bibliográficos
Autores principales: Schneemann, Martina, Heils, Lucas, Moos, Verena, Weiß, Franziska, Krug, Susanne M., Weiner, January, Beule, Dieter, Gerhard, Ralf, Schulzke, Jörg-Dieter, Bücker, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674794/
https://www.ncbi.nlm.nih.gov/pubmed/37999506
http://dx.doi.org/10.3390/toxins15110643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674794/
https://www.ncbi.nlm.nih.gov/pubmed/37999506
http://dx.doi.org/10.3390/toxins15110643

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