Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters

Pibrentasvir (PIB) has been demonstrated to block exonuclease activity of the SARS-CoV-2 polymerase, protecting favipiravir (FVP) and remdesivir (RDV) from post-incorporation excision and eliciting antiviral synergy in vitro. The present study investigated the chemoprophylactic efficacy of PIB, FVP,...

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Detalles Bibliográficos
Autores principales: Gallardo-Toledo, Eduardo, Neary, Megan, Sharp, Joanne, Herriott, Joanne, Kijak, Edyta, Bramwell, Chloe, Curley, Paul, Arshad, Usman, Pertinez, Henry, Rajoli, Rajith K. R., Valentijn, Anthony, Cox, Helen, Tatham, Lee, Kipar, Anja, Stewart, James P., Owen, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675045/
https://www.ncbi.nlm.nih.gov/pubmed/38005839
http://dx.doi.org/10.3390/v15112161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675045/
https://www.ncbi.nlm.nih.gov/pubmed/38005839
http://dx.doi.org/10.3390/v15112161

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