Cargando…

Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters

Pibrentasvir (PIB) has been demonstrated to block exonuclease activity of the SARS-CoV-2 polymerase, protecting favipiravir (FVP) and remdesivir (RDV) from post-incorporation excision and eliciting antiviral synergy in vitro. The present study investigated the chemoprophylactic efficacy of PIB, FVP,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gallardo-Toledo, Eduardo, Neary, Megan, Sharp, Joanne, Herriott, Joanne, Kijak, Edyta, Bramwell, Chloe, Curley, Paul, Arshad, Usman, Pertinez, Henry, Rajoli, Rajith K. R., Valentijn, Anthony, Cox, Helen, Tatham, Lee, Kipar, Anja, Stewart, James P., Owen, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675045/ https://www.ncbi.nlm.nih.gov/pubmed/38005839 http://dx.doi.org/10.3390/v15112161

Ejemplares similares

Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays
por: Box, Helen, et al.
Publicado: (2022)

Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters
por: Neary, Megan, et al.
Publicado: (2023)

Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case
por: Tatham, Lee, et al.
Publicado: (2023)

Development of a highly sensitive bioanalytical assay for the quantification of favipiravir.
por: Curley, Paul, et al.
Publicado: (2021)

Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research.
por: Neary, Megan, et al.
Publicado: (2021)

Generation of transgenic golden Syrian hamsters
por: Gao, Mingming, et al.
Publicado: (2014)

Golden Syrian Hamster Models for Cancer Research
por: Wang, Zhongde, et al.
Publicado: (2022)

SARS-CoV-2 Disease Severity in the Golden Syrian Hamster Model of Infection Is Related to the Volume of Intranasal Inoculum
por: Handley, Alastair, et al.
Publicado: (2023)

The production of skin lesions and lymphocytic leukemia in the Syrian (golden) hamster.
por: Fortner, J. G.
Publicado: (1965)

Rift Valley Fever Virus Infection in Golden Syrian Hamsters
por: Scharton, Dionna, et al.
Publicado: (2015)

An immunosuppressed Syrian golden hamster model for SARS-CoV infection
por: Schaecher, Scott R., et al.
Publicado: (2008)

Phytosterols protect against diet-induced hypertriglyceridemia in Syrian golden hamsters
por: Rideout, Todd C, et al.
Publicado: (2014)

Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis
por: Wang, Yunan, et al.
Publicado: (2016)

Pathogenesis and transmission of SARS-CoV-2 in golden Syrian hamsters
por: Sia, Sin Fun, et al.
Publicado: (2020)

Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters
por: Vesin, Benjamin, et al.
Publicado: (2022)

RELATION OF CERTAIN ENDOCRINE DISTURBANCES TO SUSCEPTIBILITY OF GOLDEN SYRIAN HAMSTER TO EXPERIMENTAL POLIOMYELITIS
por: Teodoru, Constantin V., et al.
Publicado: (1954)

Chronic effects of dietary exposure to amosite and chrysotile asbestos in Syrian golden hamsters.
por: McConnell, E E, et al.
Publicado: (1983)

Validation of assays to monitor immune responses in the Syrian golden hamster (Mesocricetus auratus)
por: Zivcec, Marko, et al.
Publicado: (2011)

Efficient Gene Targeting in Golden Syrian Hamsters by the CRISPR/Cas9 System
por: Fan, Zhiqiang, et al.
Publicado: (2014)

Corrigendum: Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis
por: Wang, Yunan, et al.
Publicado: (2016)

Pathogenesis and Host Response in Syrian Hamsters following Intranasal Infection with Andes Virus
por: Safronetz, David, et al.
Publicado: (2011)

Depletion of Alveolar Macrophages Does Not Prevent Hantavirus Disease Pathogenesis in Golden Syrian Hamsters
por: Hammerbeck, Christopher D., et al.
Publicado: (2016)

Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters
por: Westover, Jonna B., et al.
Publicado: (2018)

The golden (Syrian) hamster as a model for the study of reproductive biology: Past, present, and future
por: Hirose, Michiko, et al.
Publicado: (2018)

A novel cancer syndrome caused by KCNQ1-deficiency in the golden Syrian hamster
por: Li, Rong, et al.
Publicado: (2018)

Using a Syrian (Golden) Hamster Biological Model for the Evaluation of Recombinant Anthrax Vaccines
por: Kravchenko, Tatiana, et al.
Publicado: (2021)

Pharmacokinetic modelling to estimate intracellular favipiravir ribofuranosyl-5′-triphosphate exposure to support posology for SARS-CoV-2
por: Pertinez, Henry, et al.
Publicado: (2021)

Distribution and photodynamic effect of disulphonated aluminium phthalocyanine in the pancreas and adjacent tissues in the Syrian golden hamster.
por: Nuutinen, P. J., et al.
Publicado: (1991)

The Effect of Concomitant Ethanol and Opium Consumption on Lipid Profiles and Atherosclerosis in Golden Syrian Hamster’s Aorta
por: Shahryari, Jahanbanoo, et al.
Publicado: (2013)

Antihyperlipidemic and Antioxidant Effects of C-phycocyanin in Golden Syrian Hamsters Fed with a Hypercholesterolemic Diet
por: Sheu, Ming-Jyh, et al.
Publicado: (2013)

Viral MicroRNA Effects on Pathogenesis of Polyomavirus SV40 Infections in Syrian Golden Hamsters
por: Zhang, Shaojie, et al.
Publicado: (2014)

The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet
por: Pu, Shichen, et al.
Publicado: (2020)

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
por: Qiao, Wei, et al.
Publicado: (2022)

Vasculitis and Neutrophil Extracellular Traps in Lungs of Golden Syrian Hamsters With SARS-CoV-2
por: Becker, Kathrin, et al.
Publicado: (2021)

Severe Acute Respiratory Syndrome Coronavirus 2 Vasculopathy in a Syrian Golden Hamster Model
por: Ball, Erin E., et al.
Publicado: (2023)

Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics
por: Arshad, Usman, et al.
Publicado: (2020)

Dose prediction for repurposing nitazoxanide in SARS‐CoV‐2 treatment or chemoprophylaxis
por: Rajoli, Rajith K. R., et al.
Publicado: (2020)

Selectivity of the photosensitiser Tookad® for photodynamic therapy evaluated in the Syrian golden hamster cheek pouch tumour model
por: Borle, F, et al.
Publicado: (2003)

Distribution and photodynamic effects of meso-tetrahydroxyphenylchlorin (mTHPC) in the pancreas and adjacent tissues in the Syrian golden hamster.
por: Mlkvy, P., et al.
Publicado: (1996)

Nasal Associated Lymphoid Tissue of the Syrian Golden Hamster Expresses High Levels of PrP(C)
por: Clouse, Melissa D., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_urqh49pq8tif3jbidigchffua7