Cargando…

Targeting 7KCh-Induced Cell Death Response Mediated by p38, P2X7 and GSDME in Retinal Pigment Epithelium Cells with Sterculic Acid

Age-related macular degeneration (AMD) is the main cause of blindness in developed countries. AMD is characterized by the formation of drusen, which are lipidic deposits, between retinal pigment epithelium (RPE) and the choroid. One of the main molecules accumulated in drusen is 7-Ketocholesterol (7...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pariente, Ana, Peláez, Rafael, Ochoa, Rodrigo, Pérez-Sala, Álvaro, Villanueva-Martínez, Ángela, Bobadilla, Miriam, Larráyoz, Ignacio M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675123/ https://www.ncbi.nlm.nih.gov/pubmed/38004569 http://dx.doi.org/10.3390/pharmaceutics15112590

Ejemplares similares

Identification of 7-Ketocholesterol-Modulated Pathways and Sterculic Acid Protective Effect in Retinal Pigmented Epithelium Cells by Using Genome-Wide Transcriptomic Analysis
por: Pariente, Ana, et al.
Publicado: (2023)

Genome-Wide Transcriptomic Analysis Identifies Pathways Regulated by Sterculic Acid in Retinal Pigmented Epithelium Cells
por: Pariente, Ana, et al.
Publicado: (2020)

Sterculic Acid Alters Adhesion Molecules Expression and Extracellular Matrix Compounds to Regulate Migration of Lung Cancer Cells
por: Peláez, Rafael, et al.
Publicado: (2021)

Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases
por: Peláez, Rafael, et al.
Publicado: (2020)

Pretreatment of human retinal pigment epithelial cells with sterculic acid forestalls fenretinide-induced apoptosis
por: William, Samuel, et al.
Publicado: (2022)

p53–GSDME Elevation: A Path for CDK7 Inhibition to Suppress Breast Cancer Cell Survival
por: Wang, Yueyuan, et al.
Publicado: (2021)

Biomarkers as Predictive Factors of Anti-VEGF Response
por: Bobadilla, Miriam, et al.
Publicado: (2022)

Complete Genome Sequences of the p1 Gene Type 2b and 2c Strains Mycoplasma pneumoniae KCH-402 and KCH-405
por: Kenri, Tsuyoshi, et al.
Publicado: (2017)

Effect of 7-methylxanthine on human retinal pigment epithelium cells cultured in vitro
por: Wan, Wenjuan, et al.
Publicado: (2017)

Pigment Epithelium-Derived Factor Induces Endothelial Barrier Dysfunction via p38/MAPK Phosphorylation
por: He, Ting, et al.
Publicado: (2015)

Integrins: Moonlighting Proteins in Invadosome Formation
por: Peláez, Rafael, et al.
Publicado: (2019)

Sterculic Acid and Its Analogues Are Potent Inhibitors of Toxoplasma gondii
por: Hao, Pan, et al.
Publicado: (2016)

Predictive Biomarkers of Age-Related Macular Degeneration Response to Anti-VEGF Treatment
por: Oca, Ana I., et al.
Publicado: (2021)

Promoting GSDME expression through DNA demethylation to increase chemosensitivity of breast cancer MCF-7 / Taxol cells
por: Gong, Weihua, et al.
Publicado: (2023)

Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells
por: Venn, Neil, et al.
Publicado: (2008)

The Impact of Pigment-Epithelium-Derived Factor on MCF-7 Cell Metabolism in the Context of Glycaemic Condition
por: Abooshahab, Raziyeh, et al.
Publicado: (2023)

Purification and initial characterization of Plasmodium falciparum K(+) channels, PfKch1 and PfKch2 produced in Saccharomyces cerevisiae
por: Molbaek, Karen, et al.
Publicado: (2020)

BMP7 retards peripheral myelination by activating p38 MAPK in Schwann cells
por: Liu, Xiaoyu, et al.
Publicado: (2016)

Beyond KCH selection and options in acute liver failure
por: Bernal, William, et al.
Publicado: (2018)

Conversion of t11t13 CLA into c9t11 CLA in Caco-2 Cells and Inhibition by Sterculic Oil
por: Schneider, Anne-Catherine, et al.
Publicado: (2012)

Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo.
por: Khoo, D. E., et al.
Publicado: (1991)

William Frederic Chambers, K.C.H. M.D., F.R.S., F.R.C.P.
por: Rolleston, Humphry
Publicado: (1942)

Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis
por: Lo, Sheng-Min, et al.
Publicado: (2022)

GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis
por: Yang, Xiuxiu, et al.
Publicado: (2020)

GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis
Publicado: (2022)

7-Ketocholesterol enhances leukocyte adhesion to endothelial cells via p38MAPK pathway
por: Tani, Mariko, et al.
Publicado: (2018)

Cascade biotransformation of estrogens by Isaria fumosorosea KCh J2
por: Kozłowska, Ewa, et al.
Publicado: (2019)

Retinal Pigment Epithelium Derived Stem Cells
por: Hiscott, Paul, et al.
Publicado: (2009)

B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation
por: Wang, Xiaojie, et al.
Publicado: (2012)

Activation of JNK and p38 in MCF-7 Cells and the In Vitro Anticancer Activity of Alnus hirsuta Extract
por: Ryu, Mina, et al.
Publicado: (2020)

Highly Enantioselective Production of (R)-Halohydrins with Whole Cells of Rhodotorula rubra KCh 82 Culture
por: Janeczko, Tomasz, et al.
Publicado: (2014)

GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells
por: Li, Fang, et al.
Publicado: (2022)

Impact of KChIP2 on Cardiac Electrophysiology and the Progression of Heart Failure
por: Grubb, Søren, et al.
Publicado: (2012)

Glycosylation of 6-methylflavone by the strain Isaria fumosorosea KCH J2
por: Dymarska, Monika, et al.
Publicado: (2017)

Glycosylation of Methoxylated Flavonoids in the Cultures of Isaria fumosorosea KCH J2
por: Dymarska, Monika, et al.
Publicado: (2018)

KChIP2 is a core transcriptional regulator of cardiac excitability
por: Nassal, Drew M, et al.
Publicado: (2017)

Oleic acid induces A7r5 cell proliferation and migration associated with increased expression of HGF and p-p38
por: Li, Jingjing, et al.
Publicado: (2021)

Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes
por: Gong, Lili, et al.
Publicado: (2018)

Pigment Epithelium-Derived Factor Secreted from Retinal Pigment Epithelium Facilitates Apoptotic Cell Death of iPSC
por: Kanemura, Hoshimi, et al.
Publicado: (2013)

Pulsed Electromagnetic Fields Increase Pigmentation through the p-ERK/p-p38 Pathway in Zebrafish (Danio rerio)
por: Kim, Yu-Mi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_otjsk3sh1l9kdi43577h4trqra