Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery

MbtI from Mycobacterium tuberculosis (Mtb) is a Mg(2+)-dependent salicylate synthase, belonging to the chorismate-utilizing enzyme (CUE) family. As a fundamental player in iron acquisition, MbtI promotes the survival and pathogenicity of Mtb in the infected host. Hence, it has emerged in the last de...

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Detalles Bibliográficos
Autores principales: Mori, Matteo, Villa, Stefania, Chiarelli, Laurent R., Meneghetti, Fiorella, Bellinzoni, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675255/
https://www.ncbi.nlm.nih.gov/pubmed/38004425
http://dx.doi.org/10.3390/ph16111559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675255/
https://www.ncbi.nlm.nih.gov/pubmed/38004425
http://dx.doi.org/10.3390/ph16111559

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