Repurposing Synthetic Congeners of a Natural Product Aurone Unveils a Lead Antitumor Agent Inhibiting Folded P-Loop Conformation of MET Receptor Tyrosine Kinase

A library of 24 congeners of the natural product sulfuretin were evaluated against nine panels representing nine cancer diseases. While sulfuretin elicited very weak activities at 10 µM concentration, congener 1t was identified as a potential compound triggering growth inhibition of diverse cell lin...

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Detalles Bibliográficos
Autores principales: Hassan, Ahmed H. E., Wang, Cai Yi, Lee, Cheol Jung, Jeon, Hye Rim, Choi, Yeonwoo, Moon, Suyeon, Lee, Chae Hyeon, Kim, Yeon Ju, Cho, Soo Bin, Mahmoud, Kazem, El-Sayed, Selwan M., Lee, Sang Kook, Lee, Yong Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675456/
https://www.ncbi.nlm.nih.gov/pubmed/38004462
http://dx.doi.org/10.3390/ph16111597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675456/
https://www.ncbi.nlm.nih.gov/pubmed/38004462
http://dx.doi.org/10.3390/ph16111597

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