N-Succinylaspartic-Acid-Conjugated Riluzole Is a Safe and Potent Colon-Targeted Prodrug of Riluzole against DNBS-Induced Rat Colitis

In our previous study, riluzole azo-linked to salicylic acid (RAS) was prepared as a colon-targeted prodrug of riluzole (RLZ) to facilitate the repositioning of RLZ as an anticolitic drug. RAS is more effective against rat colitis than RLZ and sulfasalazine, currently used as an anti-inflammatory bo...

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Detalles Bibliográficos
Autores principales: Kim, Jaejeong, Kang, Changyu, Yoo, Jin-Wook, Yoon, In-Soo, Jung, Yunjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675528/
https://www.ncbi.nlm.nih.gov/pubmed/38004616
http://dx.doi.org/10.3390/pharmaceutics15112638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675528/
https://www.ncbi.nlm.nih.gov/pubmed/38004616
http://dx.doi.org/10.3390/pharmaceutics15112638

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