Design, Synthesis, and Antisickling Investigation of a Thiazolidine Prodrug of TD-7 That Prolongs the Duration of Action of Antisickling Aromatic Aldehyde

The synthetic allosteric effector of hemoglobin, TD-7 has been investigated as a potential therapeutic agent for the treatment of sickle cell disease. The pharmacologic activity of TD-7 is due to formation of a Schiff-base interaction between its aldehyde group and the two N-terminal αVal1 amines of...

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Detalles Bibliográficos
Autores principales: Alhashimi, Rana T., Ahmed, Tarek A., Alghanem, Lamya, Pagare, Piyusha P., Huang, Boshi, Ghatge, Mohini S., Omar, Abdelsattar M., Abdulmalik, Osheiza, Zhang, Yan, Safo, Martin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675597/
https://www.ncbi.nlm.nih.gov/pubmed/38004527
http://dx.doi.org/10.3390/pharmaceutics15112547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675597/
https://www.ncbi.nlm.nih.gov/pubmed/38004527
http://dx.doi.org/10.3390/pharmaceutics15112547

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