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Novel glycosyl prodrug of RXP03 as MMP-11 prodrug: design, synthesis and virtual screening
Like most phosphinic acids, the potent and selective RXP03 inhibitor of different MMPs exhibited moderate absorption and low bioavailability, which impaired its use. In an unprecedented attempt, we present an interesting synthetic approach to a new class of phosphinate prodrug, glycosyl ester of RXP...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675898/ https://www.ncbi.nlm.nih.gov/pubmed/38007463 http://dx.doi.org/10.1186/s13065-023-01075-1 |