Pioglitazone attenuates tamoxifen-induced liver damage in rats via modulating Keap1/Nrf2/HO-1 and SIRT1/Notch1 signaling pathways: In-vivo investigations, and molecular docking analysis

BACKGROUND: Tamoxifen (TAM) is a chemotherapeutic drug widely utilized to treat breast cancer. On the other hand, it exerts deleterious cellular effects in clinical applications as an antineoplastic agent, such as liver damage and cirrhosis. TAM-induced hepatic toxicity is mainly attributed to oxida...

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Detalles Bibliográficos
Autores principales: Kamel, Gellan Alaa Mohamed, Elariny, Hemat A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676319/
https://www.ncbi.nlm.nih.gov/pubmed/37934372
http://dx.doi.org/10.1007/s11033-023-08847-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676319/
https://www.ncbi.nlm.nih.gov/pubmed/37934372
http://dx.doi.org/10.1007/s11033-023-08847-x

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