ACO2 deficiency increases vulnerability to Parkinson’s disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes

Parkinson’s disease (PD) is characterized by α-synuclein aggregation in dopaminergic (DA) neurons, which are sensitive to oxidative stress. Mitochondria aconitase 2 (ACO2) is an essential enzyme in the tricarboxylic acid cycle that orchestrates mitochondrial and autophagic functions to energy metabo...

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Detalles Bibliográficos
Autores principales: Zhu, Junge, Xu, Fanxi, Lai, Hong, Yuan, Huiyao, Li, Xu-Ying, Hu, Junya, Li, Wei, Liu, Lei, Wang, Chaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676364/
https://www.ncbi.nlm.nih.gov/pubmed/38007539
http://dx.doi.org/10.1038/s42003-023-05570-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676364/
https://www.ncbi.nlm.nih.gov/pubmed/38007539
http://dx.doi.org/10.1038/s42003-023-05570-y

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