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DNA methylation-activated full-length EMX1 facilitates metastasis through EMX1-EGFR-ERK axis in hepatocellular carcinoma

Altered DNA methylation is a crucial epigenetic event in hepatocellular carcinoma (HCC) development and progression. Through methylation-transcriptomic analysis, we identified a set of sixty potential DNA methylation-based epidriver genes. In this set of genes, we focused on the hypermethylation of...

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Detalles Bibliográficos
Autores principales: Wen, Dong-sheng, Huang, Li-chang, Bu, Xiao-yun, He, Min-ke, Lai, Zhi-cheng, Du, Ze-feng, Huang, Ye-xing, Kan, Anna, Shi, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676392/
https://www.ncbi.nlm.nih.gov/pubmed/38007497
http://dx.doi.org/10.1038/s41419-023-06293-y