Expression and Biological Evaluation of an Engineered Recombinant L-asparaginase Designed by In Silico Method Based on Sequence of the Enzyme from Escherichia coli

PURPOSE: Medical usage of L-asparaginase (ASNase), the first-line of acute lymphoblastic leukemia treatment, is linked to allergic responses and toxicities, which necessitates the development of new bio-better ASNases. The aim of the current study was in silico design of a novel ASNase with predicte...

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Detalles Bibliográficos
Autores principales: Dastmalchi, Mahrokh, Alizadeh, Mahdiyeh, Jamshidi-Kandjan, Omid, Rezazadeh, Hassan, Hamzeh-Mivehroud, Maryam, Farajollahi, Mohammad M, Dastmalchi, Siavoush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676546/
https://www.ncbi.nlm.nih.gov/pubmed/38022803
http://dx.doi.org/10.34172/apb.2023.085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676546/
https://www.ncbi.nlm.nih.gov/pubmed/38022803
http://dx.doi.org/10.34172/apb.2023.085

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