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633. Nanopore Sequencing and In-house Bioinformatic Pipeline for Rapid and Accurate Detection of NRTI, NNRTI, PI, and INSTI Drug Resistance Mutations
BACKGROUND: Sanger-based sequencing (SBS) remains the gold standard for HIV-1 drug resistance testing (DRT). However, SBS output is still limited to an approximately 800-1000 bp read length. This is inadequate for amplifying the pol gene region that contains most of the clinically significant drug r...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677064/ http://dx.doi.org/10.1093/ofid/ofad500.699 |