Cargando…

292. Phosphorodiamidate Morpholino Oligomers Targeting acpP Reduce the Biofilm Burden in Burkholderia cepacia Complex

BACKGROUND: The Burkholderia cepacia complex (Bcc) is composed of highly related opportunistic species that establish pulmonary infections in immunodeficient hosts, such as those with cystic fibrosis and chronic granulomatous disease. Due to their innate antibiotic-resistant phenotypes and capacity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mendez, Antonio R, Pybus, Christine A, Greenberg, David E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Abstract
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678012/ http://dx.doi.org/10.1093/ofid/ofad500.364

Ejemplares similares

In Vitro Validation of Phosphorodiamidate Morpholino Oligomers
por: Aung-Htut, May T., et al.
Publicado: (2019)

Antisense Phosphorodiamidate Morpholino Oligomers as Novel Antiviral Compounds
por: Nan, Yuchen, et al.
Publicado: (2018)

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo
por: Moustafa, Dina A., et al.
Publicado: (2021)

Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers
por: Li, Chengxi, et al.
Publicado: (2021)

MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice
por: Ran, Ning, et al.
Publicado: (2020)

MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli
por: Daly, Seth M., et al.
Publicado: (2017)

Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers
por: Warfield, Kelly L, et al.
Publicado: (2006)

Development of Novel Bioanalytical Methods to Determine the Effective Concentrations of Phosphorodiamidate Morpholino Oligomers in Tissues and Cells
por: Schnell, Frederick J., et al.
Publicado: (2013)

Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice
por: Mukashyaka, Marie Claire, et al.
Publicado: (2021)

A cell-penetrating peptide enhances delivery and efficacy of phosphorodiamidate morpholino oligomers in mdx mice
por: Gan, Li, et al.
Publicado: (2022)

Antiviral Phosphorodiamidate Morpholino Oligomers are Protective against Chikungunya Virus Infection on Cell-based and Murine Models
por: Lam, Shirley, et al.
Publicado: (2015)

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication
por: Victorio, Carla Bianca Luena, et al.
Publicado: (2020)

Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach
por: Tsurusaki, Taiki, et al.
Publicado: (2023)

A Single Phosphorodiamidate Morpholino Oligomer Targeting VP24 Protects Rhesus Monkeys against Lethal Ebola Virus Infection
por: Warren, Travis K., et al.
Publicado: (2015)

Combined Treatment with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomer-PPMO and AAV-U7 Rescues the Severe DMD Phenotype in Mice
por: Forand, Anne, et al.
Publicado: (2020)

Therapeutic phosphorodiamidate morpholino oligonucleotides: Physical properties, solution structures, and folding thermodynamics
por: Maksudov, Farkhad, et al.
Publicado: (2023)

Only Acyl Carrier Protein 1 (AcpP1) Functions in Pseudomonas aeruginosa Fatty Acid Synthesis
por: Ma, Jin-Cheng, et al.
Publicado: (2017)

Shorter Phosphorodiamidate Morpholino Splice-Switching Oligonucleotides May Increase Exon-Skipping Efficacy in DMD
por: Akpulat, Ugur, et al.
Publicado: (2018)

Of its five acyl carrier proteins, only AcpP1 functions in Ralstonia solanacearum fatty acid synthesis
por: Yin, Yu, et al.
Publicado: (2022)

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study
por: Cirak, Sebahattin, et al.
Publicado: (2011)

Targeting of the Essential acpP, ftsZ, and rne Genes in Carbapenem-Resistant Acinetobacter baumannii by Antisense PNA Precision Antibacterials
por: Nejad, Alireza Japoni, et al.
Publicado: (2021)

Transport of Nanoparticles and Tobramycin-loaded Liposomes in Burkholderia cepacia Complex Biofilms
por: Messiaen, Anne-Sophie, et al.
Publicado: (2013)

Commercial use of Burkholderia cepacia.
por: LiPuma, J J, et al.
Publicado: (1999)

Bacteria of the Burkholderia cepacia complex are cyanogenic under biofilm and colonial growth conditions
por: Ryall, Ben, et al.
Publicado: (2008)

Burkholderia Cepacia Endophthalmitis: An Unusual Presentation
por: Deka, Amarendra, et al.
Publicado: (2018)

Emergence of Burkholderia cepacia in ICU Setting
por: Meena, Suneeta, et al.
Publicado: (2019)

Cicero and Burkholderia cepacia: What’s in a Name?
por: Moore, John E., et al.
Publicado: (2003)

Burkholderia cepacia meningitis in the Central African Republic
por: Frank, Thierry, et al.
Publicado: (2019)

Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex
por: Suppiger, Angela, et al.
Publicado: (2013)

Influence of Neutrophil Defects on Burkholderia cepacia Complex Pathogenesis
por: Porter, Laura A., et al.
Publicado: (2011)

Binding of protegrin-1 to Pseudomonas aeruginosa and Burkholderia cepacia
por: Albrecht, Mark T, et al.
Publicado: (2002)

Burkholderia cepacia complex in Indian cystic fibrosis patients
por: Gautam, Vikas, et al.
Publicado: (2012)

Intrinsic Resistance of Burkholderia cepacia Complex to Benzalkonium Chloride
por: Ahn, Youngbeom, et al.
Publicado: (2016)

Burkholderia cepacia Complex Taxon K: Where to Split?
por: Depoorter, Eliza, et al.
Publicado: (2020)

Advances in Phage Therapy: Targeting the Burkholderia cepacia Complex
por: Lauman, Philip, et al.
Publicado: (2021)

The First Case of Burkholderia cepacia-Induced Myasthenic Crisis
por: Şahin, Ali, et al.
Publicado: (2023)

Infected aortic endograft with an unusual microbe, Burkholderia cepacia
por: Foulke, Evan E., et al.
Publicado: (2023)

An Oxygen-Sensing Two-Component System in the Burkholderia cepacia Complex Regulates Biofilm, Intracellular Invasion, and Pathogenicity
por: Schaefers, Matthew M., et al.
Publicado: (2017)

Structural and Functional Insights into the Biofilm-Associated BceF Tyrosine Kinase Domain from Burkholderia cepacia
por: Mayer, Michal, et al.
Publicado: (2021)

Advanced morpholino oligomers: A novel approach to antiviral therapy
por: Warren, Travis K., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_esi62isgburptvumbjofak6r72