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2520. A Phase 1b Study of the Safety, Pharmacokinetics, and Ex Vivo Tick Killing of the Lyme Prophylaxis Candidate TP-05
BACKGROUND: In the U.S., Lyme disease is the most common vector-borne disease caused by infection with B. burgdorferi bacteria following a bite by a tick vector. TP-05 (lotilaner oral capsule), an isoxazoline, is a selective inhibitor of insect and acarine GABA mediated chloride channels, which para...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678042/ http://dx.doi.org/10.1093/ofid/ofad500.2138 |