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2144. A Phase 1, Multicenter, Open-Label, Parallel-Group Study to Assess the Safety and Pharmacokinetics (PK) of Oral Epetraborole Tablets in Adult Subjects with Varying Degrees of Renal Function

BACKGROUND: Epetraborole (EBO), an orally available bacterial leucyl transfer RNA synthetase inhibitor with potent activity against nontuberculous mycobacteria, is in clinical development for treatment-refractory MAC lung disease. The objective of the study was to evaluate EBO PK in adult subjects w...

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Detalles Bibliográficos
Autores principales: Patel, Gina, Canas, George C, Cruz, Kimberly, Marbury, Thomas C, Gotfried, Mark, Chan, Wallace (Boon Chun), Duchin, Kenneth, Maier, Gary, Chanda, Sanjay, Kammerer, Linda, Long, Jennifer, Moore, Stephanie, O’Shea, Kevin, Shafiee, Afshin, Smith, Alex, Eckburg, Paul B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678051/
http://dx.doi.org/10.1093/ofid/ofad500.1767