A critical role of retinoic acid concentration for the induction of a fully human-like atrial action potential phenotype in hiPSC-CM

Retinoic acid (RA) induces an atrial phenotype in human induced pluripotent stem cells (hiPSCs), but expression of atrium-selective currents such as the ultrarapid (I(Kur)) and acetylcholine-stimulated K(+) current is variable and less than in the adult human atrium. We suspected methodological issu...

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Detalles Bibliográficos
Autores principales: Schulz, Carl, Sönmez, Muhammed, Krause, Julia, Schwedhelm, Edzard, Bangfen, Pan, Alihodzic, Dzenefa, Hansen, Arne, Eschenhagen, Thomas, Christ, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679650/
https://www.ncbi.nlm.nih.gov/pubmed/37922915
http://dx.doi.org/10.1016/j.stemcr.2023.10.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679650/
https://www.ncbi.nlm.nih.gov/pubmed/37922915
http://dx.doi.org/10.1016/j.stemcr.2023.10.006

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