Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects

A complete knockout of a single key pluripotency gene may drastically affect embryonic stem cell function and epigenetic reprogramming. In contrast, elimination of only one allele of a single pluripotency gene is mostly considered harmless to the cell. To understand whether complex haploinsufficienc...

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Detalles Bibliográficos
Autores principales: Lasry, Rachel, Maoz, Noam, Cheng, Albert W., Yom Tov, Nataly, Kulenkampff, Elisabeth, Azagury, Meir, Yang, Hui, Ople, Cora, Markoulaki, Styliani, Faddah, Dina A., Makedonski, Kirill, Orzech, Dana, Sabag, Ofra, Jaenisch, Rudolf, Buganim, Yosef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679652/
https://www.ncbi.nlm.nih.gov/pubmed/37832543
http://dx.doi.org/10.1016/j.stemcr.2023.09.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679652/
https://www.ncbi.nlm.nih.gov/pubmed/37832543
http://dx.doi.org/10.1016/j.stemcr.2023.09.009

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