PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes

The direct conversion of human skin fibroblasts to neurons has a low efficiency and unclear mechanism. Here, we show that the knockdown of PTBP2 significantly enhanced the transdifferentiation induced by ASCL1, MIR9/9(∗)-124, and p53 shRNA (AMp) to generate mostly GABAergic neurons. Longitudinal RNA...

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Detalles Bibliográficos
Autores principales: Zhu, Binglin, Fisher, Emily, Li, Li, Zhong, Ping, Yan, Zhen, Feng, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679656/
https://www.ncbi.nlm.nih.gov/pubmed/37832540
http://dx.doi.org/10.1016/j.stemcr.2023.09.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679656/
https://www.ncbi.nlm.nih.gov/pubmed/37832540
http://dx.doi.org/10.1016/j.stemcr.2023.09.012

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