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PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes
The direct conversion of human skin fibroblasts to neurons has a low efficiency and unclear mechanism. Here, we show that the knockdown of PTBP2 significantly enhanced the transdifferentiation induced by ASCL1, MIR9/9(∗)-124, and p53 shRNA (AMp) to generate mostly GABAergic neurons. Longitudinal RNA...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679656/ https://www.ncbi.nlm.nih.gov/pubmed/37832540 http://dx.doi.org/10.1016/j.stemcr.2023.09.012 |