A novel FOXP3 knockout-humanized mouse model for pre-clinical safety and efficacy evaluation of Treg-like cell products

Forkhead box P3 (FOXP3) is an essential transcription factor for regulatory T cell (Treg) function. Defects in Tregs mediate many immune diseases including the monogenic autoimmune disease immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), which is caused by FOXP3 mutat...

Descripción completa

Detalles Bibliográficos
Autores principales: Sato, Yohei, Nathan, Abinaya, Shipp, Suzette, Wright, John Fraser, Tate, Keri Marie, Wani, Prachi, Roncarolo, Maria-Grazia, Bacchetta, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679769/
https://www.ncbi.nlm.nih.gov/pubmed/38027059
http://dx.doi.org/10.1016/j.omtm.2023.101150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679769/
https://www.ncbi.nlm.nih.gov/pubmed/38027059
http://dx.doi.org/10.1016/j.omtm.2023.101150

Ejemplares similares