Cargando…

Super-enhancer driven SOX2 promotes tumor formation by chromatin re-organization in nasopharyngeal carcinoma

BACKGROUND: Nasopharyngeal carcinoma (NPC) is a malignant head and neck cancer with a high incidence in Southern China and Southeast Asia. Patients with remote metastasis and recurrent NPC have poor prognosis. Thus, a better understanding of NPC pathogenesis may identify novel therapies to address t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Shang-Xin, Wang, Chong, Lin, Ruo-Bin, Ding, Wei-Yue, Roy, Gaurab, Wang, Hong-Bo, Yang, Ting, Liu, Qian, Luo, Yi-Ling, Jin, Shui-Lin, Zeng, Mu-Sheng, Zhao, Bo, Zhong, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679863/ https://www.ncbi.nlm.nih.gov/pubmed/37967508 http://dx.doi.org/10.1016/j.ebiom.2023.104870

Ejemplares similares

Super Enhancer Driven Hyaluronan Synthase 3 Promotes Malignant Progression of Nasopharyngeal Carcinoma
por: Chen, Quanzhu, et al.
Publicado: (2023)

METTL3‐stabilized super enhancers‐lncRNA SUCLG2‐AS1 mediates the formation of a long‐range chromatin loop between enhancers and promoters of SOX2 in metastasis and radiosensitivity of nasopharyngeal carcinoma
por: Hu, Xinyu, et al.
Publicado: (2023)

Landscape and significance of human super enhancer-driven core transcription regulatory circuitry
por: Feng, Chenchen, et al.
Publicado: (2023)

SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway
por: Lei, Xin-Xing, et al.
Publicado: (2020)

SOX1 acts as a tumor hypnotist rendering nasopharyngeal carcinoma cells refractory to chemotherapy
por: Lei, Xin-Xing, et al.
Publicado: (2023)

The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis
por: Liu, Chia-Feng, et al.
Publicado: (2015)

Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
por: Jiang, Yuan, et al.
Publicado: (2018)

Upregulated Expression of SOX4 Is Associated with Tumor Growth and Metastasis in Nasopharyngeal Carcinoma
por: Shi, Si, et al.
Publicado: (2015)

MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4
por: Jiang, Chengyi, et al.
Publicado: (2017)

[Retracted] MicroRNA‑212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4
por: Jiang, Chengyi, et al.
Publicado: (2023)

Super-Resolution Microscopy of Chromatin
por: Birk, Udo J.
Publicado: (2019)

SOX1 down-regulates β-catenin and reverses malignant phenotype in nasopharyngeal carcinoma
por: Guan, Zhong, et al.
Publicado: (2014)

Dissecting super-enhancer hierarchy based on chromatin interactions
por: Huang, Jialiang, et al.
Publicado: (2018)

Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5
por: Hattori, Takako, et al.
Publicado: (2008)

SOX9 reprograms endothelial cells by altering the chromatin landscape
por: Fuglerud, Bettina M, et al.
Publicado: (2022)

Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site
por: Zhang, Shui-xing, et al.
Publicado: (2014)

High expression of Sox10 correlates with tumor aggressiveness and poor prognosis in human nasopharyngeal carcinoma
por: Zhao, Yu, et al.
Publicado: (2016)

Sox transcription in sarcosine utilization is controlled by Sigma(54) and SoxR in Bacillus thuringiensis HD73
por: Peng, Qi, et al.
Publicado: (2016)

Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis
por: Liu, Li-na, et al.
Publicado: (2013)

Super-resolution microscopy reveals decondensed chromatin structure at transcription sites
por: Wang, Yejun, et al.
Publicado: (2014)

Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA
por: Nguyen, Tuan, et al.
Publicado: (2022)

XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells
por: Ji, Jiao, et al.
Publicado: (2018)

Different chromatin-scanning modes lead to targeting of compacted chromatin by pioneer factors FOXA1 and SOX2
por: Lerner, Jonathan, et al.
Publicado: (2023)

The Super-scan and Flare Phenomena in a Nasopharyngeal Cancer Patient: A Case Report
por: Lu, Min-Chuan, et al.
Publicado: (2012)

Radiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study
por: Liu, Ting, et al.
Publicado: (2023)

Sox2-Dependent 3D Chromatin Interactomes in Transcription, Neural Stem Cell Proliferation and Neurodevelopmental Diseases
por: Wei, Chia-Lin, et al.
Publicado: (2019)

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation
por: Blassberg, Robert, et al.
Publicado: (2022)

Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus
por: Taylor, Tiegh, et al.
Publicado: (2022)

Diagnostic Value of Nasopharyngeal Aspirates in Children with Lower Respiratory Tract Infections
por: Lu, Ai-Zhen, et al.
Publicado: (2017)

Favorable prognosis of female patients with nasopharyngeal carcinoma
por: Lu, Xing, et al.
Publicado: (2013)

Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance
por: Bertolini, Jessica A., et al.
Publicado: (2019)

Targeted gene therapy of nasopharyngeal cancer in vitro and in vivo by enhanced thymidine kinase expression driven by human TERT promoter and CMV enhancer
por: Shen, Cong-Xiang, et al.
Publicado: (2010)

Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
por: Xu, Jianquan, et al.
Publicado: (2020)

Coupling chromatin structure and dynamics by live super-resolution imaging
por: Barth, R., et al.
Publicado: (2020)

Fluorescence-based super-resolution-microscopy strategies for chromatin studies
por: Burgers, Thomas C. Q., et al.
Publicado: (2023)

MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma
por: Bissey, Pierre-Antoine, et al.
Publicado: (2020)

The Suppressive Role of SOX7 in Hepatocarcinogenesis
por: Wang, Chong, et al.
Publicado: (2014)

HOTAIR mediates cisplatin resistance in nasopharyngeal carcinoma by regulating miR-106a-5p/SOX4 axis
por: Cao, Wei, et al.
Publicado: (2022)

Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells
por: Wang, Hong-Bo, et al.
Publicado: (2015)

Aberrant super-enhancer-driven oncogene ENC1 promotes the radio-resistance of breast carcinoma
por: Li, Lin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dmhe13cb124ga89j45v088v9ge